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Drug intelligence / Profile preview
2-deoxy-2-[18F]fluoro-D-sorbitol
- Development stage
- Unknown
- Lead developer
- Johns Hopkins University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
2-deoxy-2-[18F]fluoro-D-sorbitol (18F-FDS) is a radiolabeled sorbitol analog used as a positron emission tomography (PET) imaging agent. It is specifically designed to visualize and differentiate infections caused by Enterobacterales (Gram-negative bacteria) and certain fungal pathogens (such as Aspergillus, Rhizopus, and Mucor) from sterile inflammation and cancer. 18F-FDS is selectively taken up and metabolized by these microorganisms via sorbitol-specific pathways, while showing minimal uptake in mammalian cells and Gram-positive bacteria. It is also utilized for functional renal imaging due to its rapid clearance through renal filtration. 18F-FDS can be synthesized via a simple, one-step reduction of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG).
- Other names
- 18F-FDS18F-fluorodeoxysorbitol2-deoxy-2-[18F]fluoro-D-sorbitol2-deoxy-2-[18F]fluorosorbitol2-deoxy-2-18F-fluoro-D-sorbitol2-deoxy-2-fluoro-D-sorbitol F-18[18F]2-fluoro-2-deoxy-sorbitol[18F]FDS[18F]fluorodeoxysorbitolfluorodeoxysorbitolfluorodeoxysorbitol F-18
02
Targets
S6PDH (Sorbitol-6-phosphate dehydrogenase)PTS (Phosphoenolpyruvate-dependent sugar phosphotransferase system)SORD (Sorbitol dehydrogenase)
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